Journal article
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis
G Fiorito, C McCrory, O Robinson, C Carmeli, CO Rosales, Y Zhang, E Colicino, PA Dugué, F Artaud, GJ McKay, A Jeong, PP Mishra, TH Nøst, V Krogh, S Panico, C Sacerdote, R Tumino, D Palli, G Matullo, S Guarrera Show all
Aging | Published : 2019
Abstract
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. The four..
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Grants
Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This research was supported by the 'Lifepath' grant to Paolo Vineis at Imperial College, London, Silvia Polidoro at the Italian Institute for Genomic Medicine (IIGM). The Airwave Health Monitoring Study is funded by the Home Office (grant number 780-TETRA) with additional support from the National Institute for Health Research (NIHR) Biomedical Research Centre. The Airwave Study uses the computing resources of the UK MEDical BIOinformatics partnership (UK MED-BIO supported by the Medical Research Council (MR/L01632X/1). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The DNA methylation data was funded by the Genetic Laboratory of the Department of Internal Medicine, Erasmus Medical Center, and by the Netherlands Organization for Scientific Research (NWO; project number 184021007) and made available as a Rainbow Project (RP3; BIOS) of the Biobanking and Biomolecular Research Infrastructure Netherlands (BBMRI-NL). TILDA project was supported by the Irish Government, the Atlantic Philanthropies, and Irish Life plc. The SKIPOGH study was supported by a grant from the Swiss National Science Foundation (FN 33CM30-124087); DNA methylation data in the SKIPOGH data was funded by the Swiss national Science Foundation (AmbizioneGrant no PZ00P3_167732 to Silvia Stringhini) and European commission and the Swiss State Secretariat for Education, Research and Innovation -SERI (Horizon 2020 grant no 633666). We are grateful to all the participants of NICOLA, Dr Laura Smyth and the NICOLA team, which includes nursing staff, research scientists, clerical staff, computer and laboratory technicians, managers and receptionists. This work was supported by the following funders who provide core financial support for the NICOLA Study: the Atlantic Philanthropies; the Economic and Social Research Council; the UKCRC Centre of Excellence for Public Health Northern Ireland; the Centre for Ageing Research and Development in Ireland; the Office of the First Minister and Deputy First Minister; the Health and Social Care Research and Development Division of the Public Health Agency; the Wellcome Trust/Wolfson Foundation; and Queen's University Belfast. The MCCS component of this work was supported by the Australian National Health and Medical Research Council (NHMRC, grants 1074383 and 1106016). MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by NHMRC grants 209057 and 396414 and by infrastructure provided by Cancer Council Victoria, and the methylation studies were supported by NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616, 1074383 and 1088405. The Young Finns Study has been financially supported by the Academy of Finland: grants 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation, Wihuri Foundation (for L-PR); Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation. DNA methylation data for the TERRE study was funded through the multilateral France-Germany-Canada Call for International proposals 2015 on "Epigenomics of complex diseases" (Agence nationale de la recherche grant ANR-15-EPIG-0001) as part of the DECIPHER-PD project. Oliver Robinson was supported by a MRC Early Career Fellowship. Carolina Ochoa-Rosales work was funded by the CONICYT PAI/INDUSTRIA 72170524, Chile. Cathal McCrory is supported by a HRB Emerging Investigator Award (EIA-2017-12). We are grateful to all the participants of NICOLA, and the NICOLA team, which includes nursing staff, research scientists, clerical staff, computer and laboratory technicians, managers and receptionists.